Associate Professor, MD, PhD
I work at the Department of Neuroscience at Karolinska Institutet. I have had a Postdoctoral fellowship at Yale University School of Medicine, New Haven, CT, USA. I have held a senior research position in Integrative Systems Neurobiology awarded by the Swedish Research Council.
I’m interested in how the neuronal networks of the brain drive basic survival functions such as social coexistence and aggression, food intake, reproduction and the switch between sleep and wakefulness. My research team focuses on the hypothalamus, an evolutionarily ancient part of the brain that plays a key role in initiating, organizing and terminating such behaviours. Through experimental studies on animal models we aim to answer questions such as:
How does the pregnant mother’s brain prepare for motherhood? – How do neurons with heterogeneous properties cooperate to produce homogenous network activity? – What makes us choose between different behaviours in different situations? – How does the neuron know that it’s running out of transmitter substance? – Which mechanisms can awake the sleeping brain?
In parallel to my research, I have taken an interest in how science is organized, evaluated and financed. These issues were at the core of my tenure as Vice President (2011-12), President (2012-13) and Spokesperson on research policy (2013-16) for the Young Academy of Sweden.
Three recently published works:
- Lyons DJ, Hellysaz A, Broberger C, 2016. Serotonin and SSRIs Inhibit Rat Tuberoinfundibular Dopamine (TIDA) Neurons: Implications for the Sexual Side Effects of Anti-Depressants, Journal of Neuroscience, 36(28):7392-406.
- Stagkourakis S, Kim H, Lyons DJ, Broberger C, 2016. Dopaminergic Autoreceptor Regulation of a Hypothalamic Dopamine Network
Cell Reports., Apr 14. pii: S2211-1247(16)30333-3. [Epub ahead of print].
- Case L, Lyons DJ, Broberger C, 2016. Desynchronization of the rat cortical network and excitation of white matter neurons by neurotensin Cerebral Cortex, Apr 19. pii: bhw100. [Epub ahead of print].
Three frequently cited works:
- Lyons DJ, Hellysaz A, Broberger C, 2012. Prolactin Regulates Tuberoinfundibular Dopamine (TIDA) Neuron Discharge Pattern: Novel Feedback Control Mechanisms in the Lactotrophic Axis J. Neurosci. ; 32(23):8074-83.
- Lyons DJ, Horjales E, Broberger C, 2010. A slow oscillation in tuberoinfundibular dopamine (TIDA) neurons: Switch to tonic firing via thyrotropin-releasing hormone (TRH) Neuron; 65(2): 217-29.
- Foo K, Brismar H, Broberger C, 2008. Distribution and neuropeptide coexistence of nesfatin-1/nucleobindin2 mRNA in the rat brain.